Seb Carreno Lab
Cell Biology of Cell Division
We are studying the molecular networks that regulate cell morphogenesis during mitosis and migration.
These two processes being critical for cancer metastasis, our research will help identify novel cellular targets to design new therapeutics against cancer.
Dividing Drosophila S2 cell expressing fluorescently labelled tubulin (green) and actin (red). Requires Flash
Our main goal is to study how the cytoskeleton remodels the cell cortex during mitosis and migration and how impairment of these functions is implicated in carcinogenesis.
The cytoskeleton is a diverse, multi-protein framework that
plays fundamental roles in multiple biological processes
with direct relevance to oncology, including cell division
and motility. Generating one specific cell shape that
promotes one specific biological function relies on local
remodeling of the acto-myosin cortex controlled by
polarization signals sent by the microtubule network. During
mitosis, cells undergo a stereotyped series of shape
transformations to achieve segregation of their cytoplasmic
content and genomic material. The microtubule spindle
separates the chromosomes, and is necessary to signal acto-myosin
contractions at the metaphase plate. These equatorial
contractions trigger formation of the cleavage furrow that
achieves cytokinesis. This microtubule/acto-myosin crosstalk
also regulates cell morphogenesis during cell motility. The
microtubule array sends polarization signals that locally
modify cell shape to control directionality of migration.